Endocrine Abstracts

Introduction and objectives: Transsexuality refers to discrepancy between the assigned sex/gender at birth and the one that the subject identifies with. The use of the cross hormone treatment as sex/gender change method implies the necessity of monitorize the hormone levels and potential treatment risks. Our study tries to evaluate the relationship between the hormone changes and the changes in the cardiovascular risk factors and the bone mineral density.<p class="abstext"...

Introduction: Hereditary phaeochromocytoma (PCC) and paraganglioma (PGL) account for 30–35% of cases and have some clinically relevant peculiarities.Material and methods: Retrospective, unicentric cohort study that included all genotyped patients (n=36, 27 with PCC and 9 with PGL) diagnosed at Hospital Clínico San Carlos (Madrid) between 1984 and 2013; 33% were germline mutation carriers (25% pseudohypoxic [PH] phenotype, 75% MAP-kinas...

Introduction: Hereditary Medullary Thyroid Cancer (MTC) accounts for 20–30% of cases and has some clinically relevant peculiarities.Material and methods: Retrospective, unicentric cohort study that included all genotyped patients with MTC (n=48) diagnosed at Hospital Clínico San Carlos (Madrid) between 1984–2013; 42% were germline mutation carriers (45% moderate risk (category MOD), 45% high risk (category H), 10% highest risk (ca...

Introduction: Hyponatremia(HN) is frequent in the emergency room(ER), yet often ignored, or poorly studied/managed. Our objective was to determine the characteristics of patients presenting HN at the ER of a general hospital.Methods: Retrospective analysis of all 347 patients(AllP) presenting/developing non-translocational HN (serum sodium (SNa)<135 mmol/l) the first 48 h at the Hospital Clinico San Carlos ER in August 2012. Volemia was determined by...

Introduction: Endogenous Cushing’s syndrome (CS) is a rare, infradiagnosed and severe disease that carries high morbidity and mortality. Delays in treatment initiation reduce reversibility of symptoms and increase mortality rate. Current gold standard for screening, 24 h urinary free cortisol, has a low reproducibility and specificity, and sampling is complicated. Midnight salivary cortisol (MSVC) determination is considered an easy and cheap test. We intend to assess its...